Sodium Stibogluconate uses and warning

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Item Description
Generic Name Sodium Stibogluconate
Drug Class Antiprotozoal (Pentavalent Antimonial)
Brand Name Pentostam
Dosage Form Injection solution (vial)
Route of Administration Intravenous or intramuscular (under medical supervision only)
Indications - Visceral leishmaniasis
- Cutaneous leishmaniasis
- Mucocutaneous leishmaniasis
Side Effects - Nausea, vomiting
- Headache, dizziness
- Injection site pain
- Cardiac arrhythmias (QT prolongation)
Contraindications - Hypersensitivity to antimony compounds
- Severe renal or hepatic impairment
- Pregnancy (use only if clearly needed)
Mechanism of Action Inhibits parasite energy metabolism and enzyme systems leading to death
Pharmacokinetics - Absorption: Rapid after injection
- Elimination: Renal
- Half-life: 2–4 hours

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